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Diflucan is the best antifungal drug

Being synthesized in 1982 in the laboratory of the French company «Pfhizer», Diflucan refers to triazole antifungal group. It is well-known under the name "Fluconazole" and is used to treat fungal infections successfully. Find out more about the principle of work of Diflucan, which contraindications and side effects it has before using the drug. And sure consult your doctor before starting the treatment course as Diflucan is a serious drug despite being relatively safe. Here you will find all necessary information to take a decision if Diflucan suits your condition or not. Don’t forget to warn your healthcare specialist about any individual allergic reactions to one of the drug’s components.

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Which diagnoses are treated prescribing Diflucan?

Diflucan is effective for many diagnoses, the most common use of this medication is for skin lesions, meningitis, yeast or yeast fungi. Among other diseases requiring Diflucan treatment are the following: Candida spp, Cryptococcus neoformans, dermatophytes (Trichophyton spp.), some fungi (Hist capsulatum, Bl. dermatitides), dimorphic forms (Cocc. immitis).

Diflucan and its mechanism of action

Diflucan has the main active component fluconazole that is able to inhibit the metabolic processes in the cell fungi binding and inhibiting cytochrome P-450, which is present in most number of fungal cells’ enzyme systems. Diflucan performs several important functions in the body by blocking the processes of formation of the protective cell membrane, inhibiting the synthesis of sterols, enhancing the permeability and disrupting the damaged membranes’ recovery.

What should you know about Diflucan

Diflucan has the following advantages:

  • It is possible to use drug once a day due to its long half-life and enjoy good results immediately.
  • It is absorbed from the gastrointestinal tract within 2 hours.
  • Its effectiveness doesn’t depend on the mealtime.
  • It is excreted from in an unmodified form by kidneys.
  • It doesn’t penetrate into the brain and bone tissue.

How to treat thrush with Diflucan?

Thrush is an unpleasant disease, which affects genitals and refers to the fungal mucous membranes. These are candida vulvitis, vulvovaginitis in women, Candida balanoposthitis in men characterized by specific clinical symptoms.

Diflucan is recommended to be used as the part of the complex treatment if there is an acute form of vulvovaginal candidiasis and vulvitis. It is possible to use Diflucan systematically.

The usual dose 150 mg should be taken not depending on the mealtime. Wash the drug down with a large amount of water regardless of having meal. Sometimes men also suffer from this health problem. In this case it is necessary to provide the topical treatment with antifungal creams, ointments with the same dose and frequency as Diflucan for females. Remember that having sexual relations during the treatment course is strongly forbidden.

If there is the chronic vulvovaginal candidiasis, the patient should be examined in order to find the exact reason, which provokes the re-development of thrush with the intake of Diflucan twice a day with 3 days interval. Then you should take 150 mg on the 1st day of the menstrual cycle for half a year or one year. There is no any difference in treating this infection in males and females.

Contraindications of Diflucan

There are absolute and relative contraindications which are listed here. Check out if your health condition is one of them. Absolute contraindications include the intolerance to the drug’s ingredients and combining Diflucan with terfenadine, or cisapride. As for the relative contraindications, they are the following:

  • Hepatic and renal failure,
  • Age of the patient under 18 or over 65 years,
  • Heart diseases,
  • Pregnancy and lactation (according to the instructions the use of Diflucan during pregnancy or lactation is possible only if the benefit to the mother outweighs the potential risk to the fetus).

Possible side effects of Diflucan

Diflucan has relatively not many adverse reactions, however, there are some of them, which should be taken into account while using the drug. It is not obligatory to experience side effects but they are possible. See your doctor in case you have experienced some of them:

  • From the side of CNS: headache, dizziness, convulsions.
  • Dermatological reactions: rash, alopecia, exfoliative skin conditions including Stevens-Johnson syndrome, Lyell's syndrome (toxic epidermal necrolysis).
  • From the side of the digestive system: abdominal pain, diarrhea, flatulence, nausea, hepatotoxicity (including rare cases with fatal outcome), increased alkaline phosphatase, bilirubin, increase in serum transaminases (ALT and AST).
  • Patients with serious diseases (AIDS, cancer), have reported changes in blood counts, kidney and liver while using the drug, however, nobody knows for sure that Diflucan was the reason of these effects.
  • Allergic reactions: anaphylaxis, angioedema, face edema, pruritus.
  • From the side of metabolism: increased cholesterol and triglyceride levels in plasma, hypokalemia.
  • From the side of the hematopoietic system: leukopenia, including neutropenia and agranulocytosis, thrombocytopenia.

Among other side effects a change of taste has also been reported.

What to do in case you overdose Diflucan?

Follow prescriptions and don’t overdose the amount of Diflucan as the clinical tests have showed that some patients who did it were unlucky to experience hallucinations and paranoid behavior. However, all signs of such condition are going to disappear within 48 hours. But in any case you shouldn’t stay alone if there are hallucinations. The most reasonable solution will be to spend these 48 hours in the hospital being under the control of specialists, who can provide the required medical help.

Which drugs may be used as analogs of Diflucan?

Here you will find drugs, which are considered to be Diflucan analogs that can be used instead of Diflucan: Medoflyukon, Vero Fluconazole, Mikomaks, Disorel-Sanovel, Diflazon, Maicon. However, before you change the drug during the treatment course, it is necessary to consult your doctor if it doesn’t influence the result of the treatment.