Retin-a Acne is a common problem of both men and women and not only when you are a teenager. Retin-A 0.05 has proven to be an efficient acne treatment, which will be helpful for everybody who suffers from such annoying problem as skin imperfections. Find out more about the use of Retinol, its advantages and possible side effects by reading instructions below.

To buy Retin-A go to official pharmacy please.

Indications to use Retin-A

Retin-A should be used in the following cases:

  • for ingestion: acute promyelocytic leukemia (for the induction of remission) in patients who didn’t have the prior therapy
  • for external use: acne vulgaris (including the formation of comedones, papules, pustules), drain acne, disease of Favre Rakusho (nodular cystic elastosis skin with comedones).

As for the doses of Retin-A, they should be prescribed individually taking into account the medical testimony, stage of disease, schemes of antitumoral therapy. It is necessary to use Retin-A only after seeing the doctor who will examine you.

How does Retin-A work?

Retin A is a retinoid, which structure resembles Vitamin A. It is a natural retinol metabolite. The mechanism of action in acute promyelocytic leukosis is based on the damage that is caused by tretinoin connection with nuclear receptors of retinoic acid.

Which functions does Retin-A perform?

Retin-A has the following functions:

  1. It is responsible for enhancing cell proliferation in the papillary layer of the skin.
  2. It decreases the adhesion of cells, which are involved in the formation of acne vulgaris.
  3. It equalizes skin without causing inflammation.
  4. It is used in the treatment of open acne skin surface.
  5. It is used to treat the closed form of acne: Retin facilitates their transition into the open pimples or papules.
  6. It is able to prevent appearance of new acne.

Are there any adverse reactions caused by Retin-A?

Before using Retin-A it is recommended to get acquainted with the possible side effects. Check out the list of side effects, which can appear while you use Retin-A:

  • Dermatological reactions: dermatoxerasia, rash, cheilitis; erythema, itching, sweating, cellulitis, alopecia, exfoliative dermatitis, dry mucous membranes, xerophthalmia.
  • Retinoic acid syndrome: the common signs are fever, dyspnea, acute respiratory distress syndrome, pulmonary infiltrates, hyperskeocytosis, hypotension, pleural effusion, renal and hepatic failure.
  • From the side of the digestive system: dry mouth, nausea, vomiting, increase in liver transaminases; rare – abdominal pain, diarrhea, constipation, stomatitis, bullous.
  • From the side of the metabolism: possible increase in plasma concentrations of triglycerides, cholesterol, body weight changes.
  • CNS: dizziness, impaired consciousness, increased intracranial pressure, anxiety, depression, visual and hearing impairment.
  • From the side of the respiratory system: rarely – cough, pleural effusion, nasal mucosa edema, dyspnea, pharyngitis, wheezing in the lungs, stridor.
  • From the side of the hematopoietic system: increased bleeding ( rarely).
  • From the side of cardiovascular system: arrhythmias ( in rare cases).
  • From the side of the musculoskeletal system: pain in the muscles and bones.
  • Other possible side effects: edema; rarely – fever, chills, joining infections pneumonia, septicemia, general weakness and drowsiness, pain in the chest and backache.

When used externally Retin-A may cause redness, burning, peeling of the skin at the site of application; in rare cases – swelling, blistering or crusts, photosensitivity.

If you notice at least one of the mentioned side effects, don’t hesitate to inform your doctor in order to get medical help and consultation concerning the probability to continue using Retin treatment.

Some points about Retin-A to keep in mind:

  • Use Retin-A carefully without getting into eyes, mouth, mucous membranes; in case of contact it is necessary to rinse it with water immediately.
  • Avoid sunbathing while using Retin.
  • Remember that during the 1st week of the course with Retin acne may increase.
  • Don’t combine the medication with any drugs causing desquamation of the skin, cosmetic and hygiene products that may result in skin dryness and irritation.

Are there any contraindications of using Retin-A?

Don’t use Retin-A 0.05 in the following cases:

  • If you are pregnant.
  • If you have cutaneous epithelioma history (including family).
  • If you have hypersensitivity to tretinoin.

Contraindications to use Retin-A externally:

  • acute inflammation (including eczema),
  • skin lesions,
  • wounds,
  • burns.

It is recommended to get a consultation of your healthcare specialist in the cases mentioned above.

Retin for pregnant and breastfeeding mothers

Retin-A is a serious treatment which requires to be used only by women who are sure that they are not pregnant. It is recommended to use methods of contraception not less than during one month before the treatment with Retin-A is prescribed, during the course treatment and one month after.

According to the instructions, it is possible to start using Retin-A on the 2d or 3d day of the menstrual cycle. Two weeks before starting the course of treatment it is required to do all necessary tests to ensure that there is no pregnancy. Moreover, these tests must take place on the monthly basis in order to exclude the possibility of pregnancy in patients during the entire period of Retin-A treatment.

As for the lactation, the drug can’t be used by breastfeeding mothers that’s why it is necessary to stop breastfeeding for the period of using Retin.

Is it possible to use Retin simultaneously with other drugs?

Tretinoin is metabolized in the liver with the participation of isoenzymes of the CYP450 system. This means that during the use of drugs affecting these enzymes, changes in pharmacokinetic parameters can take place. Tretinoin is able to decrease the contraceptive effect of progesterone. Don’t take Vitamin A during the course of Retin-A in order to avoid hypervitaminosis.

Analogs of Retin-A

The medication has the following analogs:

  • Renova,
  • Atralin,
  • Refissa,
  • Tretin X,
  • Lokatsid,
  • Vesanoid,
  • Tretinoin.

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